Disparities in Triple Negative Breast Cancer Among Hispanic Population Living in Latin America Versus the United States

Gabriel De la Cruz Ku, Universidad Científica del Sur, Lima, Peru.
Anshumi Desai, Division of Plastic and Reconstructive Surgery, DeWitt Daughtry Family Department of Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
Alanna Hickey, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Bryan Valcarcel, Department of Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
Carly Wareham, Department of Surgery, Tufts Medical Center, Boston, Massachusetts, USA.
Alexandra Hernandez, Department of Surgery, University of Miami Medical School, Miami, Florida, USA.
Eva Esperanza Arias-Rivera, Universidad Científica del Sur, Lima, Peru.
Diego Chambergo-Michilot, Universidad Científica del Sur, Lima, Peru.
David Linshaw, Department of Surgery, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Gonzalo Ziegler-Rodriguez, Division of Surgical Oncology, Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru.
Sarah M. Persing, Division of Plastic and Reconstructive Surgery, Tufts Medical Center, Boston, Massachusetts, USA.
Christopher Homsy, Division of Plastic and Reconstructive Surgery, Tufts Medical Center, Boston, Massachusetts, USA.
Abhishek Chatterjee, Division of Plastic and Reconstructive Surgery, Tufts Medical Center, Boston, Massachusetts, USA.
Salvatore M. Nardello, Division of Surgical Oncology, Tufts Medical Center, Boston, Massachusetts, USA.

Document Type

Journal Article

Publication Date

1-13-2025

Journal

Journal of surgical oncology

DOI

10.1002/jso.28088

Keywords

Hispanic population; Latin America; United States of America; breast cancer; triple‐negative breast cancer

Abstract

INTRODUCTION: Triple-negative breast cancer (TNBC) has a prevalence of 12%-24% in the Hispanic population. Previous research has demonstrated that disparities in healthcare access significantly influence patient outcomes. We aimed to compare the clinicopathological characteristics and outcomes of Hispanic females with TNBC living in Latin America (HPLA) to the Hispanic population in the United States (HPUS). METHODS: We evaluated two retrospective cohorts: patients diagnosed with TNBC at the Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru, during 2000-2015, and HPUS patients with TNBC from the Surveillance, Epidemiology, and End Results Program (SEER). RESULTS: A total of 2007 HPLA and 8457 HPUS patients were included. The HPLA patients were younger and more frequently lived in nonmetropolitan areas. HPLA had higher T and N (p < 0.001) stages. HPLA patients were more likely to present with Stage III disease (51.6% vs. 20.8%), while Stage IV presentations were similar 6.6% vs. 6.8%. HPLA patients with Stages I and II more frequently underwent mastectomy compared to HPUS (56.2 vs. 48.0%). HPLA patients received neoadjuvant chemotherapy (p < 0.001), adjuvant chemotherapy (p < 0.001), and radiotherapy (p < 0.001) more often. While early breast cancer stages had similar overall survival (OS) rates for both populations, HPLA patients had worse 5-year OS rates compared to HPUS patients in Stages III (39.9% vs. 52.3%, p < 0.001) and IV (4.6% vs. 10.7%, p < 0.001). CONCLUSIONS: Hispanic females living in Latin America were more frequently diagnosed with advanced stages of TNBC and more often underwent mastectomy, even in early-stage disease. When analyzing advanced stages, HPLA had worse OS rates compared to HPUS.

Department

Epidemiology

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