Pediatric T-lymphoblastic Leukemia With an Entirely Mature Immunophenotype: A Prompt and Challenging Diagnosis
Document Type
Journal Article
Publication Date
1-1-2025
Journal
Journal of pediatric hematology/oncology
Volume
47
Issue
1
DOI
10.1097/MPH.0000000000002967
Abstract
Children with T-ALL/LBL require prompt diagnosis and treatment. Flow cytometric analysis of T-lineage and immaturity markers usually leads to a straightforward diagnosis. However, rare cases of T-ALL expressing bright CD45 and lacking expression of immature markers can be a diagnostic conundrum and difficult to differentiate from mature T-cell lymphomas lacking surface CD3 expression or aberrantly expressing immature markers, which affects treatment decisions and prognosis. Here, we summarize the clinical, pathologic, and genetic features of 3 pediatric T-ALL cases with an entirely mature immunophenotype.
APA Citation
Cheng, Jinjun; Wang, Yannan; Gong, Shunyou; Wistinghausen, Birte; Jacobs, Shana; Schore, Reuven J.; and Toner, Keri, "Pediatric T-lymphoblastic Leukemia With an Entirely Mature Immunophenotype: A Prompt and Challenging Diagnosis" (2025). GW Authored Works. Paper 6081.
https://hsrc.himmelfarb.gwu.edu/gwhpubs/6081
Department
Pediatrics