Molecular epidemiology of Escherichia coli sequence type 131 and its H30 and H30-Rx subclones among extended-spectrum-β-lactamase-positive and -negative E. coli clinical isolates from the Chicago region, 2007 to 2010
Antimicrobial Agents and Chemotherapy
Volume 57, Issue 12
We assessed Escherichia coli ST131 and its H30 and H30-Rx subclones for virulence genes, antimicrobial resistance, and extended-spectrum beta-lactamase (ESBL) type. Although both subclones were associated with ESBL production, H30-Rx isolates had higher resistance scores and were associated specifically with CTX-M-15. Three virulence genes (iha, sat, and iutA) were more prevalent among H30 than non-H30 ST131 isolates. Thus, the H30 and H30-Rx subclones are more antimicrobial resistant and have virulence profiles that are distinct from those of non-H30 ST131 isolates.
Banerjee, R., Robicsek, A., Kuskowski, M. A., Porter, S., Johnston, B. D., Sokurenko, E., Tschesnokova, V., Price, L.B., Johnson, J. R. (2013). Molecular epidemiology of escherichia coli sequence type 131 and its H30 and H30-rx subclones among extended-spectrum-β-lactamase-positive and -negative E. coli clinical isolates from the chicago region, 2007 to 2010. Antimicrobial Agents and Chemotherapy, 57(12), 6385-6388.